Wednesday, February 15, 2006

Zicam

This is from an email newsletter put out by a naturopath here in Denver. Thought it was interesting enough to post here since I have had many patients sing the praises of Zicam recently.

Zicam claims to be homeopathic Zincum gluconicum in 1 x potency. What this means in English is that it is a 10% solution of zinc gluconate. Typically homeopathic remedies are sold in much more dilute solutions. For example a 6 x potency is one part in a million of the original substance. A 12 x potency is one part in a billion. A 30 x potency is so dilute that there isn’t even a molecule of the original substance left. This is why homeopathic medicines are considered safe; there is little or nothing left to cause harm. In the case of Zicam, by calling it homeopathic and adopting the homeopathic terminology, the manufacturer found a way to market a 10% solution of zinc gluconate without FDA oversight. In other words Zicam is just an intranasal zinc solution. Intranasal zinc has been known to destroy the ability to smell in both animals and people. In the 1930s, zinc compounds were used in attempts to prevent polio. About 10% of the people who received the zinc compounds lost their sense of smell permanently. For years there had been no attempt to use intranasal zinc in humans. However because Zincam products fall under the homeopathic provision of FDA laws, these products are not required to get FDA approval before they were put on the market.By the way loss of smell is called anosmia. It is not even clear that these products are useful for treating colds. While two placebo-controlled trials found that intranasal zinc gluconate modestly shortened the duration of cold symptoms two other placebo-controlled studies found intranasal zinc to be of no benefit.In the most rigorously controlled of these studies, intranasal zinc gluconate did not affect the severity or duration of cold symptoms in volunteers inoculated with rhinovirus, a common cause of colds. These studies did find evidence of anosmia and warned about the condition. The reports stated that since zinc-associated anosmia may be irreversible. Earlier this month the manufacturers of Zicam agreed to pay $12 million dollars to settle a class action law suit brought by 340 consumers who had lost their ability to smell after using Zicam products. The company which made $46 million dollars in the first 9 months of 2005 does not plan to take their products off the market. Even with settling the lawsuits the products are still very profitable.Some people have told me they find Zicam an effective aid in treating their symptoms. Yet if we heed Hippocrates’ injunction to, First, Do no harm, we must consider Zicam an unacceptable risk and suggest not using it..

by Jacob Schor ND

Tuesday, February 07, 2006

Kids Health Link


With the cold/flu season upon us, here is a link for some questions you may have regarding illnesses and their signs and symptoms.
http://kidshealth.org/index.html

Wednesday, February 01, 2006

Bird Flu Cases Rise

Tally of Human Bird Flu Cases Rises to 160

Hot spices and Leaky Gut

Hot spices influence permeability of human intestinal epithelial monolayers.Jensen-Jarolim E, Gajdzik L, Haberl I, Kraft D, Scheiner O, Graf J.Department of General and Experimental Pathology, University Hospital AKH, Logo, Vienna, Austria.Indirect evidence suggests that hot spices may interact with epithelial cells of the gastrointestinal tract to modulate their transport properties. Using HCT-8 cells, a cell line from a human ileocoecal carcinoma, we studied the effects of spices on transepithelial electrical resistance (TER), permeability for fluorescein isothiocyanate (FITC)-labeled dextrans with graded molecular weight, and morphological alterations of tight junctions by immunoflu! orescence using an anti-ZO-1 antibody, a marker for tight junction integrity. Two different reactivity patterns were observed: paprika and cayenne pepper significantly decreased the TER and increased permeability for 10-, 20- and 40-kDa dextrans but not for -70 kDa dextrans. Simultaneously, tight junctions exhibited a discontinuous pattern. Applying extracts from black or green pepper, bay leaf or nutmeg increased the TER and macromolecular permeability remained low. Immunofluorescence ZO-1 staining was preserved. In accordance with the above findings, capsaicin transiently reduced resistance and piperine increased resistance, making them candidates for causing the effects seen with crude spice extracts. The observation that Solanaceae spices (paprika, cayenne pepper) increase permeability for ions and macromolecules might be of pathophysiological importance, particularly with respect to food allergy and intolerance.


From Jo Phillips- DFH